3q29 deletion syndrome may be associated with treatment-resistant psychotic symptoms. Treatment response did not clearly differ according to developmental history. Additionally, three individuals received clozapine one of whom partially responded, while two exhibited a good response. Four individuals had a poor treatment response to non-clozapine antipsychotic medications, three had a partial response, and one individual’s response to treatment was not described, despite having taken psychotropic medications of some kind. Five articles that collectively described eight individuals were included. A review of the literature was completed in December 2022 for English language articles that described treatment response to antipsychotic medications in affected individuals with schizophrenia-like presentations. As such, the purpose of this article was to review treatment response in 3q29 deletion syndrome-associated psychosis. Although this syndrome may confer the greatest risk for schizophrenia of any copy number variation, response to antipsychotic medication has infrequently been described in the literature, and no reviews on the topic currently exist. 3q29 deletion syndrome is characterized by various developmental abnormalities, medical issues, and neuropsychiatric symptoms, including psychosis.
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